• EFFECT OF HYPEROXIA ON MAXIMAL OXYGEN UPTAKE, BLOOD ACID-BASE BALANCE, AND LIMITATIONS TO EXERCISE TOLERANCE. Todd A. Astorino And Robert A. Robergs. JEPonline. 2003;6(2):8-20. Hyperoxia, or an increase in inspired oxygen concentration, has been used by scientists to examine exercise metabolism and physical work capacity. It is apparent that hyperoxia increases VO2max and exercise tolerance due to an increase in O2 supply to contracting muscle. Furthermore, hyperoxia increases PaO2, which may promote an enhanced diffusion of O2 in skeletal muscle. Compared to normoxia, hyperoxia may reduce PCr degradation during the metabolic transient, attenuating the magnitude of cellular disturbance characteristic of near-maximal to maximal exercise. These aforementioned increases in exercise tolerance
    during hyperoxia are not due to alterations in ventilation, lactate (La ), or acid/base balance in hyperoxia, as previous data report no change in these parameters compared to normoxia. In addition, it is recommended that researchers take special precautions to ensure the accuracy of gas exchange data in hyperoxia.

  • Supplemental Oxygen improves Exercise Endurance in IPF
  • J, Suchý & Heller, Jan & Bunc, Vaclav. (2010). The effect of inhaling concentrated oxygen on performance during repeated anaerobic exercise. Biology of Sport. 27. . 10.5604/20831862.919335. The objective of the pilot study was to test the effect of inhaling 99.5% oxygen on recovery. The source of concentrated oxygen was O-PUR (Oxyfit). Research subjects completed two thirty-second Wingate tests at an interval of ten minutes, and in the interval between the tests the subjects inhaled either oxygen or a placebo in random order. This procedure was then repeated. The pilot study revealed a significantly (p<0.03) smaller performance drop in the second Wingate test following the inhalation of 99.5% oxygen when compared with the placebo. The results of the study indicate that inhaling concentrated oxygen may have a positive effect on short-term recovery processes.


  • SCHOLEY, A. B., M. C. MOSS, N. NEAVE AND K. WESNES. Cognitive performance, hyperoxia, and heart rate fol- lowing oxygen administration in healthy young adults. PHYSIOL BEHAV 67(5) 783–789, 1999.—It was recently established that supplemental oxygen administration significantly enhances memory formation in healthy young adults. In the present study, a double-blind, placebo-controled design was employed to assess the cognitive and physiological effects of subjects’ in- spiration of oxygen or air (control) prior to undergoing simple memory and reaction-time tasks. Arterial blood oxygen satu- ration and heart rate were monitored during each of six phases of the experiment, corresponding to baseline, gas inhalation, word presentation, reaction time, distractor and word recall, respectively. The results confirm that oxygen administration sig- nificantly enhances cognitive performance above that seen in the air inhalation condition. Subjects who received oxygen re- called more words and had faster reaction times. Moreover, compared to participants who inhaled air, they exhibited signifi- cant hyperoxia during gas administration, word presentation, and the reaction-time task, but not at other phases of the experiment. Compared to baseline, heart rate was significantly elevated during the word presentation, reaction-time, and dis- tractor tasks in both the air and oxygen groups. In the oxygen group, significant correlations were found between changes in oxygen saturation and cognitive performance. In the air group, greater changes in heart rate were associated with more im- proved cognitive performance. These results are discussed in the context of cognitive demand and metabolic supply. It is sug- gested that under periods of cognitive demand a number of physiological responses are brought into play that serve to in- crease the delivery of metabolic substrates to active neural tissue. These mechanisms can be supplemented by increased availability of circulating blood oxygen, resulting in an augmentation of cognitive performance. Heart rate reactivity and the capacity for increased blood oxygen appear to be important physiological individual differences mediating these phenomena. © 1999 Elsevier Science Inc.